Methanol → HCID 9883399, compound

HRID 329450Notes

Reaction equation

HRID 329450 reaction equation
Br[CH:2](C)[C:3]([C:8]1[CH:9]=[CH:10][C:11]([S:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[C:12]([CH2:14][C:15]([O:17]C)=[O:16])[CH:13]=1)(OC)OC.[C:27](=O)([O-:29])[O-:28].[K+].[K+].CO>O>[C:27]([CH:3]([C:8]1[CH:9]=[CH:10][C:11]([S:19][C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)=[C:12]([CH2:14][C:15]([OH:17])=[O:16])[CH:13]=1)[CH3:2])([OH:29])=[O:28]

Participants

5

Reactant 3

HCID 887MethanolHCID 11430Potassium CarbonateHCID 14126641HCID 14126641, compound

Product 1

HCID 9883399HCID 9883399, compoundYield 76.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 4.39 g (10 mmol.) of methyl 5-(2-bromo-1,1-dimethoxypropyl)-2-phenylthiophenylacetate obtained in Example 1-(2), 3.45 g (25 mmol.) of anhydrous potassium carbonate, 13 ml of methanol and 13 ml of water was heated under reflux and stirring for 40 hours. The reaction mixture was treated in the same manner as in Example 6-(1) to obtain 2.41 g of the desired product as white crystals (yield 76%), m.p. 145°-146° C.

Workup

  1. temperatureunder reflux

Sources & evidence

ORD record
ord-365f9da4b5014dcb8fed9140e2260f1a
Source dataset
uspto-grants-1990_01
Patent number
US04891433

Reaction notes

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