反应详情

To a mixture of 2.46 g p-[5-(1-imidazolyl)pentyloxy]phenol, 24 ml ethanol and 1.75 g potassium carbonate, was added 2.1 g 1-bromonoane, and the resulting mixture was heated under reflux with stirring for two days. The solvent was distilled off under reduced pressure, the residue was extracted with chloroform, and the extract was washed with water, dehydrated and concentrated. The crude product thus obtained was purified by silica gel column chromatography, affording 0.88 g of [p-[5-(1-imidazolyl)pentyloxy]phenoxy]nonane.

1. additionwas added 2.1 g 1-bromonoane
2. temperaturethe resulting mixture was heated
3. temperatureunder reflux
4. distillationThe solvent was distilled off under reduced pressure
5. extractionthe residue was extracted with chloroform
6. washthe extract was washed with water
7. concentrationconcentrated
8. customThe crude product thus obtained
9. customwas purified by silica gel column chromatography