Thiazole → HCID 131716225, compound

HRID 329499Notes

Reaction equation

[CH2:1]([NH:18][C:19](=[O:38])[O:20][C@H:21]1[CH2:26][CH2:25][CH2:24][O:23][C@H:22]1[CH2:27][O:28][C:29](=[O:37])[NH:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][Br:36])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].[S:39]1[CH:43]=[CH:42][N:41]=[CH:40]1>>[Br-:36].[CH2:1]([NH:18][C:19]([O:20][C@H:21]1[CH2:26][CH2:25][CH2:24][O:23][C@H:22]1[CH2:27][O:28][C:29]([NH:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][N+:41]1[CH:42]=[CH:43][S:39][CH:40]=1)=[O:37])=[O:38])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]

Participants

Reactant 2

HCID 9256Thiazole

HCID 70373939HCID 70373939, compound

Product 1

HCID 131716225HCID 131716225, compound

Procedure

Following a procedure similar to that described in Example 4 but using 550.2 mg of dl-cis-2-[N-(5-bromopentyl)carbamoyloxy]methyltetrahydropyran-3-yl N-heptadecylcarbamate (prepared as described in Preparation 67) and 0.65 ml of thiazole, 526.9 mg of the title compound was obtained as a white powder, melting at 115°-120° C.

Sources & evidence

ORD record: ord-2b0669f28d8d4585a6f6d23c650dc156
Source dataset: uspto-grants-1990_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04891363

Reaction notes

Loading…