HCID 67870777, compound → HCID 67870769, compound

HRID 329524Notes

Reaction equation

HRID 329524 reaction equation
[CH2:1]([NH:18][C:19](=[O:36])[O:20][C@H:21]1[CH2:26][CH2:25][CH2:24][O:23][C@H:22]1[CH2:27][O:28]CC1C=CC=CC=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]>C(O)C.[Pd]>[CH2:1]([NH:18][C:19](=[O:36])[O:20][C@H:21]1[CH2:26][CH2:25][CH2:24][O:23][C@H:22]1[CH2:27][OH:28])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]

Participants

4

Reactant 1

HCID 67870777HCID 67870777, compound

Product 1

HCID 67870769HCID 67870769, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Following a procedure similar to that described in Preparation 4, but using a solution of 1.300 g of dl-cis-2-benzyloxymethyltetrahydropyran-3-yl N-heptadecylcarbamate (prepared as described in Preparation 65) in 30 ml of ethanol and 0.819 g of 10% w/w palladium on activated carbon, 0.977 g of the title compound was obtained as crystals. These crystals melted at 81.0°-82.0° C. after recrystallisation from diethyl ether.

Workup

  1. customthat described in Preparation 4

Sources & evidence

ORD record
ord-5206b26e73fc43b1a99b3b42a9828136
Source dataset
uspto-grants-1990_01
Patent number
US04891363

Reaction notes

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