Sodium Acetate → HCID 15052053, compound

HRID 329570Notes

Reaction equation

HRID 329570 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[C:17](O)=[O:18])=[O:10])[CH:5]=[CH:4][C:3]=1[CH2:20][N:21]1[C:25](=[O:26])[C:24]([CH3:28])([CH3:27])[CH2:23][O:22]1.C([O-])(=O)C.[Na+]>C(OC(=O)C)(=O)C>[Br:1][C:2]1[CH:7]=[C:6]([N:8]2[C:17](=[O:18])[C:12]3=[CH:13][CH:14]=[CH:15][CH:16]=[C:11]3[C:9]2=[O:10])[CH:5]=[CH:4][C:3]=1[CH2:20][N:21]1[C:25](=[O:26])[C:24]([CH3:28])([CH3:27])[CH2:23][O:22]1

Participants

4

Reactant 2

HCID 517045Sodium AcetateHCID 15051991HCID 15051991, compound

Product 1

HCID 15052053HCID 15052053, compound

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

This compound was prepared in a manner analogous to that of Example 10, using 2.0 grams (0.004 mole) of 2-[[2-bromo-4-[(2-carboxyphenyl)carbonylamino]phenyl]-methyl]-4,4-dimethyl-3-isoxazolidinone and 5.0 grams (0.061 mole) of sodium acetate in 50 mL of acetic anhydride. The solid was recrystallized from ethyl acetatehexane to yield 2-[(2-bromo-4-phthalimidophenyl)methyl]-4,4-dimethyl-3-isoxazolidinone; m.p. 158°-159° C.

Workup

  1. customThis compound was prepared in a manner analogous to that of Example 10
  2. customThe solid was recrystallized from ethyl acetatehexane

Sources & evidence

ORD record
ord-c2e0390775364ea18f1e0e707c8fdbdb
Source dataset
uspto-grants-1990_01
Patent number
US04892578

Reaction notes

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