HCID 12352226, compound → HCID 14086473, compound

HRID 329754Notes

Reaction equation

HRID 329754 reaction equation
[C:1]1(=[O:14])[CH:9]2[CH:4]([CH:5]3[CH2:11][CH2:10][CH:8]2[CH:7]2[CH2:12][CH:6]32)[C:3](=[O:13])[NH:2]1.[Cl:15][C:16]1[C:17]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)=[N:18][CH:19]=[CH:20][N:21]=1>>[ClH:15].[Cl:15][C:16]1[C:17]([N:22]2[CH2:23][CH2:24][N:25]([CH2:3][CH2:4][CH2:5][CH2:6][N:2]3[C:3](=[O:13])[CH:4]4[CH:9]([CH:8]5[CH2:10][CH2:11][CH:5]4[CH:6]4[CH2:12][CH:7]54)[C:1]3=[O:14])[CH2:26][CH2:27]2)=[N:18][CH:19]=[CH:20][N:21]=1

Participants

3

Reactant 2

HCID 12352226HCID 12352226, compoundHCID 140864382-Chloro-3-(piperazin-1-yl)pyrazine

Product 1

HCID 14086473HCID 14086473, compound

Procedure

The title compound is prepared following the procedure of Example 1, using hexahydro-4,6-ethanocycloprop[f]isoindole-1,3-(2H,3aH)-dione instead of hexahydro-4,7-ethenocycloprop[f]isoindole-1,3(2H,3aH)-dione and 1-(3-chloro-2-pyrazinyl)piperazine instead of 1-(6-chloro-2-pyrazinyl)piperazine hydrochloride and is converted to the hydrochloride salt; m.p. 245°-246° C.

Sources & evidence

ORD record
ord-d31be6b20bdd4d4f80c2a1e70ea7b3f3
Source dataset
uspto-grants-1990_01
Patent number
US04892943

Reaction notes

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