反应详情

2,6-dichlorothiophenol, 50.0 gm, was added to 50 ml of ethanol. 63.8 ml of a 25% solution of sodium methoxide (2 equivalents) in methanol was then added to the system. The system was stirred at room temperature for approximately 3 hours. Afterwards, 20 ml of bromoacetic acid was added and the system then heated to reflux. The system was continued at reflux for 16 hours. The reaction was then stopped and the solvent removed by stripping. The resulting material was dissolved with basic aqueous solution water and then washed with methylene chloride. Concentrated HCl was next added to the aqueous solution to acidify it. The product was extracted with methylene chloride. The methylene chloride solution was stripped and triturated with hexane. The product was then filtered, washed with water and air dried to yield 55.3 gm of the 2,6-dichlorothiophenoxyacetic acid.

1. temperaturethe system then heated to reflux
2. temperatureat reflux for 16 hours
3. customthe solvent removed by stripping
4. dissolutionThe resulting material was dissolved with basic aqueous solution water
5. washwashed with methylene chloride
6. additionConcentrated HCl was next added to the aqueous solution
7. extractionThe product was extracted with methylene chloride
8. customtriturated with hexane
9. filtrationThe product was then filtered
10. washwashed with water and air
11. customdried