反应详情

5.40 g (25 mmol) of methyl 4-methoxy-2-acetonyl-2-methylacetoacetate are held at reflux temperature for 21/2 hours with 106 ml (12.5 mmol) of 2.5% Na2CO3 solution. The reaction mixture is extracted 3 times with 150 ml of CH2Cl2 each time. The combined organic phases are dried over magnesium sulphate and concentrated on a rotary evaporator to give 2.66 g (76%) of 2-methoxy-3,5-dimethyl-2-cyclopenten-1-one, content: 96.7%.

1. extractionThe reaction mixture is extracted 3 times with 150 ml of CH2Cl2 each time
2. dry with materialThe combined organic phases are dried over magnesium sulphate
3. concentrationconcentrated on a rotary evaporator