Sodium Carbonate → 2-Cyclopenten-1-one, 2-methoxy-3,5-dimethyl-

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Reaction Steps

5.40 g (25 mmol) of methyl 4-methoxy-2-acetonyl-2-methylacetoacetate are held at reflux temperature for 21/2 hours with 106 ml (12.5 mmol) of 2.5% Na2CO3 solution. The reaction mixture is extracted 3 times with 150 ml of CH2Cl2 each time. The combined organic phases are dried over magnesium sulphate and concentrated on a rotary evaporator to give 2.66 g (76%) of 2-methoxy-3,5-dimethyl-2-cyclopenten-1-one, content: 96.7%.

Provenance & Evidence