反应详情

2.15 g (15.36 mmol) of crude 2-methoxy-3,5-dimethyl-2-cyclopenten-1-one are held at reflux temperature for 2 hours with 21.50 g (=10 fold amount by weight) of 5N hydrochloric acid. The reaction mixture is extracted 3 times with 50 ml of CH2Cl2 each time. The combined organic phases are dried over magnesium sulphate and concentrated on a rotary evaporator. After recrystallization from ether/hexane 1:1 there are obtained 1.05 g (54.2%) 2-hydroxy-3,5-dimethyl-2-cyclopenten-1-one; m.p. 92°-93° C.

1. extractionThe reaction mixture is extracted 3 times with 50 ml of CH2Cl2 each time
2. dry with materialThe combined organic phases are dried over magnesium sulphate
3. concentrationconcentrated on a rotary evaporator
4. customAfter recrystallization from ether/hexane 1:1 there