反应详情

3.08 g (22 mmol) of 3-ethyl-2-methoxy-2-cyclopenten-1-one are held at reflux temperature for 5 hours with 30.80 g of 5N hydrochloric acid. After cooling the reaction mixture is extracted 3 times with 50 ml of CH2Cl2 each time. The combined organic phases are dried over magnesium sulphate and concentrated on a rotary evaporator. The crude product is bulb-tube distilled at 0.1 mbar/110° C. and gives 1.82 g (65.7%) of 3-ethyl-2-hydroxy-2-cyclopenten-1-one (melting point 39°-41° C.).

1. temperatureAfter cooling the reaction mixture
2. extractionis extracted 3 times with 50 ml of CH2Cl2 each time
3. dry with materialThe combined organic phases are dried over magnesium sulphate
4. concentrationconcentrated on a rotary evaporator
5. distillationdistilled at 0.1 mbar/110° C.