HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 2-(4-Benzhydryl-1-piperazinyl)ethyl ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | 3-Nitrobenzaldehyde | HCID 7449 | — |
| Reactant | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| Reactant | Butanoic acid, 3-oxo-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ester | HCID 11740518 | — |
| Product | 2-(4-Benzhydryl-1-piperazinyl)ethyl ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | HCID 19871266 | 48.3% |
Reaction Steps
A mixture of m-nitrobenzaldehyde, 2-(4-benzhydryl-1-piperazinyl)ethyl acetoacetate and ethyl 3-aminocrotonate was reacted in isopropyl alcohol in the same manner as Example 1 to give 2-(4-benzhydryl-1-piperazinyl)ethyl ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate as a light yellow powder, m.p. 80°-82° C. (sintering). Yield 48.3%. IR(Nujol)cm-1 : 3320, 1695, 1680. NMR(CDCl3) δ: 1.18(3H,t,J=6,--CH2CH3), 2.33(6H,s, ##STR14## 4.08(2H,q,J=6, --CH2CH3), 4.15(2H,t,J=6, --COOCH2CH2 --), 4.18(1H,s,>N--CH<), 5.08(1H,s,C(4) --H), 5.79(1H,s,NH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04892875 |
| Source dataset | uspto-grants-1990_01 |
| ORD ID | ord-95d69f90a2884464bdb1d6f0f2247631 |
| Source note | uspto-grants-1990_01 |