反应详情

To a mixture of m-nitrobenzaldehyde (307 mg), 2-(4-benzhydryl-1-piperazinyl)ethyl acetoacetate (668 mg) and benzene (20 ml) was added piperidine (two drops), and the mixture was refluxed for 2 hours under removal of water using a Dean-Stark trap. After cooling, the reaction mixture was washed with water and dried over anhydrous sodium sulfate and the solvent was distilled off to give crude 2-(4-benzhydryl-1-piperazinyl)ethyl 2-(3-nitrobenzylidene)acetoacetate as an oil. NMR(CDCl3) δ: 2.38(3H,s,COCH3), 4.14-4.53(3H,m,--COOCH2CH2 --,>N--CH<), 7.10-8.75(14H,m). This product was submitted to the next reaction step without further purification.

1. temperatureAfter cooling
2. washthe reaction mixture was washed with water
3. dry with materialdried over anhydrous sodium sulfate
4. distillationthe solvent was distilled off