HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene → 2-(4-Benzhydryl-1-piperazinyl)ethyl 2-(3-nitrobenzylidene)acetoacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene | HCID 241 | — |
| Reactant | 3-Nitrobenzaldehyde | HCID 7449 | — |
| Reactant | Butanoic acid, 3-oxo-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ester | HCID 11740518 | — |
| Catalyst | Piperidine | HCID 8082 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-(4-Benzhydryl-1-piperazinyl)ethyl 2-(3-nitrobenzylidene)acetoacetate | HCID 54110130 | — |
Reaction Steps
To a mixture of m-nitrobenzaldehyde (307 mg), 2-(4-benzhydryl-1-piperazinyl)ethyl acetoacetate (668 mg) and benzene (20 ml) was added piperidine (two drops), and the mixture was refluxed for 2 hours under removal of water using a Dean-Stark trap. After cooling, the reaction mixture was washed with water and dried over anhydrous sodium sulfate and the solvent was distilled off to give crude 2-(4-benzhydryl-1-piperazinyl)ethyl 2-(3-nitrobenzylidene)acetoacetate as an oil. NMR(CDCl3) δ: 2.38(3H,s,COCH3), 4.14-4.53(3H,m,--COOCH2CH2 --,>N--CH<), 7.10-8.75(14H,m). This product was submitted to the next reaction step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04892875 |
| Source dataset | uspto-grants-1990_01 |
| ORD ID | ord-efa1f1afcf78487db2052d40a5470870 |
| Source note | uspto-grants-1990_01 |