Diketene → HCID 19871257, compound

HRID 329885Notes

Reaction equation

HRID 329885 reaction equation
[CH:1]([N:14]1[CH2:20][CH2:19][CH2:18][N:17]([CH2:21][CH2:22][OH:23])[CH2:16][CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:24]=[C:25]1[O:29][C:27](=[O:28])[CH2:26]1>>[C:27]([O:23][CH2:22][CH2:21][N:17]1[CH2:18][CH2:19][CH2:20][N:14]([CH:1]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:15][CH2:16]1)(=[O:28])[CH2:26][C:25]([CH3:24])=[O:29]

Participants

3

Reactant 2

HCID 12661DiketeneHCID 122365181H-1,4-Diazepine-1-ethanol, 4-(diphenylmethyl)hexahydro-

Product 1

HCID 19871257HCID 19871257, compoundYield 81.8%

Procedure

4-Benzhydrylhomopiperazine-1-ethanol (2.6 g) was reacted with diketene in the same manner as Reference Example 1-(2) to give 2-(4-benzhydrylhomopiperazin-1-yl)ethyl acetoacetate as an oil (2.7 g, 81.8%). IR(Neat): 1735, 1715 cm-1. NMR(CDCl3)δ: 1.6-1.9(2H, m), 2.26(3H, s), 2.5-2.9(10H, m), 3.40(2H, s), 4.20(2H, t, J=6), 4.57(1H, s), 7.1-7.5(10H, m).

Sources & evidence

ORD record
ord-50a286d156e84ad7ba62c714baced431
Source dataset
uspto-grants-1990_01
Patent number
US04892875

Reaction notes

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