Benzyl Bromide → HCID 767854, compound

HRID 329886Notes

Reaction equation

HRID 329886 reaction equation
[N:1]1([CH2:7][CH2:8][OH:9])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[CH2:10](Br)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[CH2:10]([N:4]1[CH2:5][CH2:6][N:1]([CH2:7][CH2:8][OH:9])[CH2:2][CH2:3]1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 7498Benzyl BromideHCID 76771-(2-Hydroxyethyl)piperazine

Product 1

HCID 767854HCID 767854, compoundYield 80.8%

Procedure

1-Piperazineethanol was benzylated with benzyl bromide in the same manner as Reference Example 1-(1) to give 4-benzyl-1-piperazineethanol as an oil. Yield 80.8%. NMR(CDCl3)δ: 2.42-2.65(10H, m), 3.33(1H, s), 3.49(2H, s), 3.59(2H, t, J=5), 7.23(5H, s).

Sources & evidence

ORD record
ord-89991a26000c475894e072135a7f74e1
Source dataset
uspto-grants-1990_01
Patent number
US04892875

Reaction notes

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