Methylamine → HCID 70357883, compound

HRID 329920Notes

Reaction equation

HRID 329920 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]([CH2:11][S:12][CH2:13][CH2:14][NH:15][C:16](SC)=[CH:17][N+:18]([O-:20])=[O:19])[CH:6]=1)[CH3:3].[CH3:23][NH2:24]>C(O)C>[N+:18]([CH:17]=[C:16]([NH:24][CH3:23])[NH:15][CH2:14][CH2:13][S:12][CH2:11][C:7]1[CH:6]=[C:5]([CH2:4][N:2]([CH3:3])[CH3:1])[CH:10]=[CH:9][N:8]=1)([O-:20])=[O:19]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 70357978HCID 70357978, compound

Product 1

HCID 70357883HCID 70357883, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 1-[2-(4-dimethylaminomethyl-2-pyridylmethylthio)ethylamino]-1-methylthio-2-nitroethylene (0.85 g) in 16% methylamine in ethanol (40 ml) was allowed to stand at ambient temperature for 36 hours. The solvent was removed in vacuo and the product was purified by chromatography on a silica gel column eluted with 15% methanol/chloroform followed by recrystallisation from acetonitrile to give 1-nitro-2-methylamino-2-[2-(4-dimethylaminomethyl-2-pyridylmethylthio)ethylamino]ethylene (0.32 g)

Workup

  1. customThe solvent was removed in vacuo
  2. customthe product was purified by chromatography on a silica gel column
  3. washeluted with 15% methanol/chloroform
  4. customfollowed by recrystallisation from acetonitrile

Sources & evidence

ORD record
ord-65882a2f66ce415088d512914561f747
Source dataset
uspto-grants-1990_01
Patent number
US04894372

Reaction notes

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