Trifluoroacetic acid → HCID 19870516, compound

HRID 330014Notes

Reaction equation

HRID 330014 reaction equation
FC(F)(F)C(O)=O.[SH:8][C:9]1[CH:18]=[CH:17][C:12]([C:13]([O:15][CH3:16])=[O:14])=[CH:11][CH:10]=1.O[CH:20]([C:27]1[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][C:28]=1[O:35][CH3:36])[CH2:21][N:22]1[CH:26]=[CH:25][N:24]=[CH:23]1>>[CH3:36][O:35][C:28]1[CH:29]=[C:30]([O:33][CH3:34])[CH:31]=[CH:32][C:27]=1[CH:20]([S:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]([O:15][CH3:16])=[O:14])=[CH:17][CH:18]=1)[CH2:21][N:22]1[CH:26]=[CH:25][N:24]=[CH:23]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 237573Methyl 4-sulfanylbenzoateHCID 19870530HCID 19870530, compound

Product 1

HCID 19870516HCID 19870516, compoundYield 40.9%

Procedure

10.9 ml of trifluoroacetic acid were added, whilst ice-cooling, to a mixture of 766 mg of methyl 4-mercaptobenzoate and 754 mg of 1-[2-hydroxy-2-(2,4-dimethoxyphenyl)ethyl]imidazole, and the resulting mixture was stirred at a temperature between 0° and 5° C. for 1.5 hours. The resulting solution was treated and purified according to the same procedure as described in Example 13, to give 495 mg of the title compound as a colorless oily substance.

Workup

  1. additionThe resulting solution was treated
  2. custompurified

Sources & evidence

ORD record
ord-ee72251cc6ba46438ad86b4df45f0129
Source dataset
uspto-grants-1990_01
Patent number
US04894385

Reaction notes

Loading…