Trifluoroacetic acid → HCID 19870533, compound

HRID 330015Notes

Reaction equation

HRID 330015 reaction equation
FC(F)(F)C(O)=O.[SH:8][C:9]1[CH:18]=[CH:17][C:12]([C:13]([O:15][CH3:16])=[O:14])=[CH:11][CH:10]=1.O[CH:20]([C:27]1[C:32]([O:33][CH3:34])=[CH:31][C:30]([O:35][CH3:36])=[CH:29][C:28]=1[O:37][CH3:38])[CH2:21][N:22]1[CH:26]=[CH:25][N:24]=[CH:23]1>>[CH3:38][O:37][C:28]1[CH:29]=[C:30]([O:35][CH3:36])[CH:31]=[C:32]([O:33][CH3:34])[C:27]=1[CH:20]([S:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]([O:15][CH3:16])=[O:14])=[CH:17][CH:18]=1)[CH2:21][N:22]1[CH:26]=[CH:25][N:24]=[CH:23]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 237573Methyl 4-sulfanylbenzoateHCID 19870522HCID 19870522, compound

Product 1

HCID 19870533HCID 19870533, compoundYield 94.3%

Procedure

13.5 ml of trifluoroacetic acid were added, whilst ice-cooling, to a mixture of 940 mg of methyl 4-mercaptobenzoate and 1.04 g of 1-[2-hydroxy-2-(2,4,6-trimethoxyphenyl)ethyl]imidazole, and the resulting mixture was stirred at a temperature between 0° and 5° C. for 2 hours. The reaction mixture was then treated and purified in a similar manner to that described in Example 13 to give 1.51 g of the title compound as a colorless oil.

Workup

  1. additionThe reaction mixture was then treated
  2. custompurified in a similar manner to that

Sources & evidence

ORD record
ord-a315a0313ea948f1b8d33c43ee9044ea
Source dataset
uspto-grants-1990_01
Patent number
US04894385

Reaction notes

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