Sodium Hydroxide → Sodium 4-[3-(4-chlorophenyl)-1-(imidazol-1-ylmethyl)propylthio]benzoate

HRID 330024Notes

Reaction equation

HRID 330024 reaction equation
[OH-].[Na+:2].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][CH:12]([CH2:24][N:25]2[CH:29]=[CH:28][N:27]=[CH:26]2)[S:13][C:14]2[CH:23]=[CH:22][C:17]([C:18]([O:20]C)=[O:19])=[CH:16][CH:15]=2)=[CH:6][CH:5]=1>CO>[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][CH:12]([CH2:24][N:25]2[CH:29]=[CH:28][N:27]=[CH:26]2)[S:13][C:14]2[CH:23]=[CH:22][C:17]([C:18]([O-:20])=[O:19])=[CH:16][CH:15]=2)=[CH:6][CH:5]=1.[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19870506Methyl 4-[3-(4-chlorophenyl)-1-(imidazol-1-ylmethyl)propylthio]benzoate

Product 1

HCID 23686288Sodium 4-[3-(4-chlorophenyl)-1-(imidazol-1-ylmethyl)propylthio]benzoate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

360 μl of a 1N aqueous solution of sodium hydroxide were added to a solution of 34 mg of methyl 4-[3-(4-chlorophenyl)-1-(imidazol-1-ylmethyl)propylthio]benzoate (prepared as described in Example 31) in 360 μl of methanol, and the resulting mixture was stirred at room temperature for 3 hours. The reaction mixture was then treated and purified by the same method as described in Example 8, to give 21 mg of the title compound as a colorless powder.

Workup

  1. additionThe reaction mixture was then treated
  2. custompurified by the same method

Sources & evidence

ORD record
ord-770e37e38bcf46c79b4e962cdb5a900d
Source dataset
uspto-grants-1990_01
Patent number
US04894385

Reaction notes

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