Hydrochloric Acid → HCID 67834421, compound

HRID 330030Notes

Reaction equation

HRID 330030 reaction equation
[OH-].[Na+].[F:3][C:4]([F:30])([F:29])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH:11]([S:18][C:19]1[CH:28]=[CH:27][C:22]([C:23]([O:25]C)=[O:24])=[CH:21][CH:20]=1)[CH2:12][N:13]1[CH:17]=[CH:16][N:15]=[CH:14]1.[ClH:31]>CO>[ClH:31].[F:30][C:4]([F:3])([F:29])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH:11]([S:18][C:19]1[CH:20]=[CH:21][C:22]([C:23]([OH:25])=[O:24])=[CH:27][CH:28]=1)[CH2:12][N:13]1[CH:17]=[CH:16][N:15]=[CH:14]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium Hydroxide2×HCID 19870524HCID 19870524, compound

Product 1

HCID 67834421HCID 67834421, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

17.6 of 1N aqueous solution of sodium hydroxide were added to 1.79 g of methyl 4-[1-(2-trifluoromethylphenyl)-2-(imidazol-1-yl)ethylthio]benzoate (prepared as described in Example 37) in 17.6 ml of methanol, and the resulting mixture was stirred at room temperature for 4.5 hours. 8.8 ml of a 1N aqueous solution of sodium hydroxide were added to the reaction mixture and it was then neutralized with 1N aqueous hydrochloric acid, after which it was treated and purified by the same method as described in Example 16, to give 1.61 g of the title compound as colorless crystals, melting at 198°-202° C.

Workup

  1. additionafter which it was treated
  2. custompurified by the same method

Sources & evidence

ORD record
ord-2af664fb56654e9b833c35b1b92360a6
Source dataset
uspto-grants-1990_01
Patent number
US04894385

Reaction notes

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