Hydrochloric Acid → HCID 13913574, compound

HRID 330032Notes

Reaction equation

HRID 330032 reaction equation
[OH-].[Na+].[CH3:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH:11]([S:18]([C:20]1[CH:29]=[CH:28][C:23]([C:24]([O:26]C)=[O:25])=[CH:22][CH:21]=1)=[O:19])[CH2:12][N:13]1[CH:17]=[CH:16][N:15]=[CH:14]1.Cl>CO>[CH3:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH:11]([S:18]([C:20]1[CH:21]=[CH:22][C:23]([C:24]([OH:26])=[O:25])=[CH:28][CH:29]=1)=[O:19])[CH2:12][N:13]1[CH:17]=[CH:16][N:15]=[CH:14]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 13913573HCID 13913573, compound

Product 1

HCID 13913574HCID 13913574, compoundYield 68.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.22 ml of a 1N aqueous solution of sodium hydroxide was added to a solution of 235 mg of methyl 4-[1-(2-methoxyphenyl)-2-(imidazol-1-yl)ethylsulfinyl]benzoate (prepared as described in Example 39) in 3 ml of methanol, and the resulting mixture was stirred at room temperature for 7 hours. The reaction mixture was then neutralized with 1.22 ml of 1N aqueous hydrochloric acid, and then treated and purified by the same method as described in Example 34, to give 155 mg of the title compound as a colorless powdery substance, melting at 157°-159° C.

Workup

  1. additiontreated
  2. custompurified by the same method

Sources & evidence

ORD record
ord-b7e740a68f98447582398dad59017a0a
Source dataset
uspto-grants-1990_01
Patent number
US04894385

Reaction notes

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