Hydrochloric Acid → HCID 13913576, compound

HRID 330033Notes

Reaction equation

HRID 330033 reaction equation
[OH-].[Na+].[CH3:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH:11]([S:18]([C:21]1[CH:30]=[CH:29][C:24]([C:25]([O:27]C)=[O:26])=[CH:23][CH:22]=1)(=[O:20])=[O:19])[CH2:12][N:13]1[CH:17]=[CH:16][N:15]=[CH:14]1.Cl>CO>[CH3:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH:11]([S:18]([C:21]1[CH:22]=[CH:23][C:24]([C:25]([OH:27])=[O:26])=[CH:29][CH:30]=1)(=[O:19])=[O:20])[CH2:12][N:13]1[CH:17]=[CH:16][N:15]=[CH:14]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 13913575HCID 13913575, compound

Product 1

HCID 13913576HCID 13913576, compoundYield 85.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.30 ml of a 1N aqueous solution of sodium hydroxide was added to 260 mg of methyl 4-[1-(2-methoxyphenyl)-2-(imidazol-1-yl)ethylsulfonyl]benzoate (prepared as described in Example 41) in 4 ml of methanol, and the resulting mixture was stirred at room temperature for 1.5 hours. At the end of this time, the resulting mixture was neutralized with 1.30 ml of 1N aqueous hydrochloric acid, and the reaction mixture was treated and purified by the same method as described in Example 34, to give 214 mg of the title compound as a colorless powdery substance, melting at 134°-138° C.

Workup

  1. additionthe reaction mixture was treated
  2. custompurified by the same method

Sources & evidence

ORD record
ord-6a305e6c4c2c416e898d9ebdcc6c6288
Source dataset
uspto-grants-1990_01
Patent number
US04894385

Reaction notes

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