Trifluoroacetic acid → HCID 19870515, compound

HRID 330034Notes

Reaction equation

HRID 330034 reaction equation
FC(F)(F)C(O)=O.[SH:8][C:9]1[CH:18]=[CH:17][C:12]([C:13]([O:15][CH3:16])=[O:14])=[CH:11][CH:10]=1.O[C:20]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[O:34][CH3:35])([CH3:27])[CH2:21][N:22]1[CH:26]=[CH:25][N:24]=[CH:23]1>>[CH3:35][O:34][C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=1[CH:20]([CH3:27])[CH:21]([N:22]1[CH:26]=[CH:25][N:24]=[CH:23]1)[S:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]([O:15][CH3:16])=[O:14])=[CH:17][CH:18]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 237573Methyl 4-sulfanylbenzoateHCID 19870531HCID 19870531, compound

Product 1

HCID 19870515HCID 19870515, compoundYield 87.6%

Procedure

5.2 ml of trifluoroacetic acid were added, whilst ice-cooling, to a mixture of 363 mg of methyl 4-mercaptobenzoate and 334 mg of 1-[2-hydroxy-2-(2-methoxyphenyl)propyl]imidazole, and the resulting mixture was stirred at 0°-5° C. for 2.5 hours. The reaction mixture was then treated and purified by the same method as described in Example 13, to give 482 mg of the title compound as a colorless oily substance.

Workup

  1. additionThe reaction mixture was then treated
  2. custompurified by the same method

Sources & evidence

ORD record
ord-c05b15240a3e4c1882571da771102895
Source dataset
uspto-grants-1990_01
Patent number
US04894385

Reaction notes

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