Hydrochloric Acid → HCID 13913571, compound

HRID 330037Notes

Reaction equation

HRID 330037 reaction equation
[OH-].[Na+].[N:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH:9]([S:16][C:17]2[CH:26]=[CH:25][C:20]([C:21]([O:23]C)=[O:22])=[CH:19][CH:18]=2)[CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)[CH:4]=1.Cl>CO>[N:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH:9]([S:16][C:17]2[CH:26]=[CH:25][C:20]([C:21]([OH:23])=[O:22])=[CH:19][CH:18]=2)[CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)[CH:4]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 19870512HCID 19870512, compound

Product 1

HCID 13913571HCID 13913571, compoundYield 55.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
40 °C

Procedure

3.39 ml of a 1N aqueous solution of sodium hydroxide were added to 575 mg of methyl-4-[1-(3-pyridyl)-2-(imidazol-1-yl)ethylthio]benzoate (prepared as described in Example 45) in 7 ml of methanol, and the resulting mixture was stirred at 40° C. for 5 hours. At the end of this time, the resulting mixture was neutralized with 3.39 ml of 1N aqueous hydrochloric acid, and the reaction mixture was treated and purified by the same method as described in Example 34, to give 305 mg of the title compound as a powder, melting at 80°-83° C.

Workup

  1. additionthe reaction mixture was treated
  2. custompurified by the same method

Sources & evidence

ORD record
ord-9f8b1e82114c48aea39af79a215c8cf0
Source dataset
uspto-grants-1990_01
Patent number
US04894385

Reaction notes

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