Trifluoroacetic acid → HCID 19870503, compound

HRID 330038Notes

Reaction equation

HRID 330038 reaction equation
[SH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][CH:3]=1.O[CH:13]([C:20]1[O:21][CH:22]=[CH:23][CH:24]=1)[CH2:14][N:15]1[CH:19]=[CH:18][N:17]=[CH:16]1.FC(F)(F)C(O)=O>>[O:21]1[CH:22]=[CH:23][CH:24]=[C:20]1[CH:13]([S:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:10][CH:11]=1)[CH2:14][N:15]1[CH:19]=[CH:18][N:17]=[CH:16]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 237573Methyl 4-sulfanylbenzoateHCID 19870517HCID 19870517, compound

Product 1

HCID 19870503HCID 19870503, compoundYield 64.2%

Procedure

3.5 g of methyl 4-mercaptobenzoate and 2.5 g of 1-[2-hydroxy-2-(2-furyl)ethyl]imidazole were mixed, and 50.7 ml of trifluoroacetic acid were added, whilst ice-cooling, to the resulting mixture. The mixture was stirred at between 0° and 5° C. for 1 hour. At the end of this time, the reaction mixture was treated and purified similarly to the procedure described in Example 13, to yield 2.96 g of the title compound as a colorless oil.

Workup

  1. temperaturecooling, to the resulting mixture
  2. additionAt the end of this time, the reaction mixture was treated
  3. custompurified similarly to the procedure

Sources & evidence

ORD record
ord-85cabda5096942beb75d8a714c46b267
Source dataset
uspto-grants-1990_01
Patent number
US04894385

Reaction notes

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