反应详情

A mixture of ethyl 2-(2,4,5-trifluoro-3-methylbenzoyl)-3-cyclopropylaminoacrylate (300 mg) and sodium fluoride (70 mg) in anhydrous DMF (2 ml) was stirred at 130° to 140° C. for 6 hours. To the reacting mixture was added ice-water (3 ml), the resulting precipitate was collected by filtration, washed with water and recrystallized from methanol to give the title compound (220 mg) as white needles, mp 220°-221° C.

1. filtrationthe resulting precipitate was collected by filtration
2. washwashed with water
3. customrecrystallized from methanol