反应详情

To the cooled mixture of 55% sodium hydride (50 mg) in anhydrous dioxane (2 ml) was added ethyl 2-(2,4,5-trifluoro-3-methylbenzoyl)-3-cyclopropylaminoacrylate (300 mg) slowly with stirring. After stirring for 30 minutes at room temperature, to the reacting mixture was added water (5 ml), the resulting precipitate was collected by filtration, washed with water and recrystallized from methanol to give the title compound (220 mg) as white needles.

1. stirringAfter stirring for 30 minutes at room temperature, to the reacting mixture
2. filtrationthe resulting precipitate was collected by filtration
3. washwashed with water
4. customrecrystallized from methanol