(1-Aminomethyl)-cyclohexaneacetic acid hydrochloride hydrate → Gabapentin hydrochloride

Beteiligte Stoffe

Reaktionsschritte

An ion exchange column is prepared by filling a glass column with 380 mL of AmberliteRIRA-68. The resin is rinsed with a dilute ammonia solution, 140 mL ammonium hydroxide in 3 L water, followed by deionized water to a neutral pH, (about 2 L). A 1 N solution of (1-aminomethyl)-cyclohexaneacetic acid hydrochloride is prepared by dissolving 64.6 g of (1-aminomethyl)-cyclohexaneacetic acid hydrochloride hydrate (4:4:1) in 310 mL of deionized water. This solution is filtered through a filter to remove any insoluble material or extracted with an organic solvent such as dichloromethane.

Herkunft & Nachweise