反应详情

温度

100 °C

136 mg of N-{2-(2-formyloxy-3-oxobutylthio)ethyl}-N'-cyano-N"-methylguanidine and 530 mg of methyl orthoformate were dissolved in 2.5 m; of formamide, and 320 mg of ammonium formate was added. The mixture was stirred at 100° C. for 2 hours. Formamide was evaporated from the reaction mixture under reduced pressure. The residue was chromatographed on a column of silica gel (eluent: chloroform/methanol=4/1), and then recrystallized from isopropanol to give 71 mg (yield 56%) of the desired product (Cimetidine) as white crystals.

1. customFormamide was evaporated from the reaction mixture under reduced pressure
2. customThe residue was chromatographed on a column of silica gel (eluent: chloroform/methanol=4/1)
3. customrecrystallized from isopropanol