Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | Ammonium formate | HCID 2723923 | — |
| Reactant | N-{2-(2-acetoxy-3-oxobutylthio)ethyl}-N'-cyano-N"-methylguanidine | HCID 14183543 | — |
| Reactant | Methylorthoformate | HCID 53629101 | — |
| Product | HCID 178484998 | HCID 178484998 | 26% |
Reaction Steps
155 mg of N-{2-(2-acetoxy-3-oxobutylthio)ethyl-}-N'-cyano-N"-methylguanidine and 290 mg of methyl orthoformate was dissolved in 2.5 ml of formamide, and 170 mg of ammonium formate was added. The mixture was stirred at 100° C. for 2 hours. The reaction mixture was treated as in Referential Example 1 to give 36 mg (yield 26%) of the desired product as white crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04894475 |
|---|
| Source dataset | uspto-grants-1990_01 |
|---|
| ORD ID | ord-5c830ece92df4f2fb26b1aaf574a6f50 |
|---|
| Source note | uspto-grants-1990_01 |
|---|
