Formamide → HCID 178484998, compound

HRID 330100Notes

Reaction equation

HRID 330100 reaction equation
C(O[CH:5]([C:17](=O)[CH3:18])[CH2:6][S:7][CH2:8][CH2:9][NH:10][C:11]([NH:14][C:15]#[N:16])=[N:12][CH3:13])(=O)C.C([O-])([O-])OC.C([O-])=O.[NH4+:28].[CH:29]([NH2:31])=O>>[C:15]([NH:14][C:11]([NH:12][CH3:13])=[N:10][CH2:9][CH2:8][S:7][CH2:6][C:5]1[N:28]=[CH:29][NH:31][C:17]=1[CH3:18])#[N:16]

Participants

5

Reactant 4

HCID 713FormamideHCID 2723923Ammonium formateHCID 14183543N-{2-(2-acetoxy-3-oxobutylthio)ethyl}-N'-cyano-N"-methylguanidineHCID 53629101Methylorthoformate

Product 1

HCID 178484998HCID 178484998, compoundYield 26%

Conditions

Temperature
100 °C

Procedure

155 mg of N-{2-(2-acetoxy-3-oxobutylthio)ethyl-}-N'-cyano-N"-methylguanidine and 290 mg of methyl orthoformate was dissolved in 2.5 ml of formamide, and 170 mg of ammonium formate was added. The mixture was stirred at 100° C. for 2 hours. The reaction mixture was treated as in Referential Example 1 to give 36 mg (yield 26%) of the desired product as white crystals.

Workup

  1. additionThe reaction mixture was treated as in Referential Example 1

Sources & evidence

ORD record
ord-5c830ece92df4f2fb26b1aaf574a6f50
Source dataset
uspto-grants-1990_01
Patent number
US04894475

Reaction notes

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