反应详情

温度

100 °C

155 mg of N-{2-(2-acetoxy-3-oxobutylthio)ethyl-}-N'-cyano-N"-methylguanidine and 290 mg of methyl orthoformate was dissolved in 2.5 ml of formamide, and 170 mg of ammonium formate was added. The mixture was stirred at 100° C. for 2 hours. The reaction mixture was treated as in Referential Example 1 to give 36 mg (yield 26%) of the desired product as white crystals.

1. additionThe reaction mixture was treated as in Referential Example 1