反应详情

To a mixture of 86 g. (0.50 mole) methyl 2,2,4-trimethyl-3-ketovalerate, 117 g. (0.64 mole) dibenzylamine hydrochloride and 19.8 g. (0.22 mole) paraformaldehyde is added a solution of 1 ml. of concentrated hydrochloric acid in 150 ml. 95% ethanol and the mixture is heated at reflux for four hours. The mixture is filtered, 500 ml. of hot acetone added to the filtrate and the resulting mixture cooled then refrigerated overnight. The precipitated product is collected by filtration, washed with acetone and dried.

1. additionTo a mixture of 86 g
2. temperatureat reflux for four hours
3. filtrationThe mixture is filtered
4. additionof hot acetone added to the filtrate
5. temperaturethe resulting mixture cooled
6. customrefrigerated overnight
7. filtrationThe precipitated product is collected by filtration
8. washwashed with acetone
9. customdried