反应详情

To a mixture of sodium borohydride (2.83 g, 0.075 mol) in methanol (150 mL) at 0° C., was added dropwise a solution of 1-chloro-2-formyl-3,4-dihydronaphthalene (9.59 g, 0.05 mol) in dry THF (150 mL). The reaction was stirred at room temperature for 1 hour, carbon dioxide was cautiously bubbled through the reaction mixture for 15 minutes, and the resulting mixture was concentrated under reduced pressure. The residue was diluted with water (150 mL), extracted with ether (3×150 mL), dried (MgSO4) and concentrated to give 9.95 g (102%) of product as a yellow oil.

1. customcarbon dioxide was cautiously bubbled through the reaction mixture for 15 minutes
2. concentrationthe resulting mixture was concentrated under reduced pressure
3. additionThe residue was diluted with water (150 mL)
4. extractionextracted with ether (3×150 mL)
5. dry with materialdried (MgSO4)
6. concentrationconcentrated