化工社化工社 化学情報印刷レポート · 研究参考用
Dimethyl Sulfate → Methyl 5-chloro-2-methoxybenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethyl Sulfate | HCID 6497 | — |
| 反応物 | 5-Chlorosalicylic Acid | HCID 9447 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | Methyl 5-chloro-2-methoxybenzoate | HCID 118574 | 99.3% |
反応手順
A mixture of 5-chlorosalicylic acid (20.0 g, 0.116 mol), potassium carbonate (40.3 g, 0.290 mol), and dimethyl sulfate (36.5 g, 0.290 mol) in acetone (300 mL) was heated at reflux for 18 hours. The mixture was cooled, concentrated, diluted with H2O, and extracted with ethyl acetate (3×150 mL). The extracts were washed with H2O and saturated NaCl, dried (MgSO4), and concentrated to give 23.10 g (99%) of product as a brown oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04895860 |
| 出典データセット | uspto-grants-1990_01 |
| ORD ID | ord-4b72682b21734a0ab04087188b707e53 |
| 出典メモ | uspto-grants-1990_01 |