反应详情

A mixture of 5-chlorosalicylic acid (20.0 g, 0.116 mol), potassium carbonate (40.3 g, 0.290 mol), and dimethyl sulfate (36.5 g, 0.290 mol) in acetone (300 mL) was heated at reflux for 18 hours. The mixture was cooled, concentrated, diluted with H2O, and extracted with ethyl acetate (3×150 mL). The extracts were washed with H2O and saturated NaCl, dried (MgSO4), and concentrated to give 23.10 g (99%) of product as a brown oil.

1. temperaturewas heated
2. temperatureat reflux for 18 hours
3. temperatureThe mixture was cooled
4. concentrationconcentrated
5. additiondiluted with H2O
6. extractionextracted with ethyl acetate (3×150 mL)
7. washThe extracts were washed with H2O and saturated NaCl
8. dry with materialdried (MgSO4)
9. concentrationconcentrated