Hydrochloric Acid → Pyridine, 2-(2-aminoethyl)-, hydrochloride

HRID 330405Notes

Reaction equation

HRID 330405 reaction equation
[ClH:1].[NH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1>C(O)C>[ClH:1].[N:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=1[CH2:4][CH2:3][NH2:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 759192-Pyridineethanamine

Product 1

HCID 212496Pyridine, 2-(2-aminoethyl)-, hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Concentrated hydrochloric acid (16.50 ml, 0.20 mole) was poured slowly into a stirred solution of 2-(2-aminoethyl)pyridine (12.22 g, 0.10 mole) in 200 ml absolute ethanol. The mixture was concentrated to dryness and the residual solid recrystallized from 600 ml absolute ethanol. The light orange-pink solid was collected and yielded 8.48 g; mp 187°-189° C. (lit1 186°-189° C.).

Workup

  1. concentrationThe mixture was concentrated to dryness
  2. customthe residual solid recrystallized from 600 ml absolute ethanol
  3. customThe light orange-pink solid was collected
  4. customyielded 8.48 g
  5. custommp 187°-189° C. (lit1 186°-189° C.)

Sources & evidence

ORD record
ord-c6ee86c5478b4eb9add5607a1318a92c
Source dataset
uspto-grants-1990_01
Patent number
US04895840

Reaction notes

Loading…