Citric Acid → HCID 17768614, compound

HRID 330418Notes

Reaction equation

HRID 330418 reaction equation
O(C[CH2:9][CH2:10][NH:11][CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)C1C=CC=CC=1.[C:20](Cl)(Cl)=[O:21].CN(C1[C:32]2[C:33](N(C)C)=[CH:34][CH:35]=[CH:36][C:31]=2C=CC=1)C.[N:40]1([CH2:45][CH2:46][NH:47][CH2:48][CH2:49][N:50]2[CH2:54][CH2:53][CH2:52][CH2:51]2)[CH2:44][CH2:43][CH2:42][CH2:41]1.C(=O)([O-])[O-:56].[Na+].[Na+].[C:61]([OH:73])(=[O:72])[CH2:62][C:63]([CH2:68][C:69]([OH:71])=[O:70])([C:65]([OH:67])=[O:66])[OH:64]>>[C:61]([OH:73])(=[O:72])[CH2:62][C:63]([CH2:68][C:69]([OH:71])=[O:70])([C:65]([OH:67])=[O:66])[OH:64].[O:56]([CH2:9][CH2:10][N:11]([CH2:12][CH2:13][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)[C:20]([N:47]([CH2:48][CH2:49][N:50]1[CH2:51][CH2:52][CH2:53][CH2:54]1)[CH2:46][CH2:45][N:40]1[CH2:41][CH2:42][CH2:43][CH2:44]1)=[O:21])[C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1

Participants

7

Reactant 6

HCID 311Citric AcidHCID 6371PhosgeneHCID 10340Sodium CarbonateHCID 88675Proton spongeHCID 14855250HCID 14855250, compoundHCID 19869583HCID 19869583, compound

Product 1

HCID 17768614HCID 17768614, compound

Procedure

N-(3-phenoxypropyl)benzeneethanamine (oil obtained in Preparation 29), phosgene (excess), Proton Sponge®, 2-(1-pyrrolidinyl)-N-[2-(1-pyrrolidinyl)ethyl]ethanamine, sodium carbonate, and treating with citric acid.

Sources & evidence

ORD record
ord-489bb97b5b674a8ab120227a6d5e2736
Source dataset
uspto-grants-1990_01
Patent number
US04895840

Reaction notes

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