Water → HCID 14626767, compound

HRID 330467Notes

Reaction equation

HRID 330467 reaction equation
[Br:1]N1C(=O)CCC1=O.[CH:9]1[C:14]2[C:15]3[N:16]([C:21]4[CH:22]=[CH:23][CH:24]=[CH:25][C:26]=4[CH:27]=3)[CH2:17][C:18](=[O:20])[NH:19][C:13]=2[CH:12]=[CH:11][CH:10]=1.O>CN(C)C=O>[Br:1][C:27]1[C:26]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[N:16]2[C:15]=1[C:14]1[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=1[NH:19][C:18](=[O:20])[CH2:17]2

Participants

5

Reactant 3

HCID 962Water2×HCID 67184N-bromobutanimideHCID 14626765HCID 14626765, compound

Product 1

HCID 14626767HCID 14626767, compoundYield 93.6%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

A solution of 2.36 g N-bromosuccinimide in 50 ml dimethylformamide was added dropwise to a solution of 3.0 g indolo[1,2-d][1,4]benzodiazepin-6(7H)-one in 50 ml dimethylformamide, during which the reaction mixture was cooled with cold water. The resulting solution was stirred at room temperature for two hours and then poured into 800 ml water. The precipitate was collected, washed with water and dried under vacuum (P2O5) to give 3.7 g solid;

Workup

  1. customThe precipitate was collected
  2. washwashed with water
  3. dry with materialdried under vacuum (P2O5)

Sources & evidence

ORD record
ord-747f61046c7941a6bbec2171a13f1df7
Source dataset
uspto-grants-1990_01
Patent number
US04897392

Reaction notes

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