HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Oxiran-2-yl)ethan-1-ol → 1-[4-(3-Chlorobenzyloxy)phenylamino] butane-2,3-diol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Oxiran-2-yl)ethan-1-ol | HCID 11593431 | — |
| Reactant | 4-[(3-Chlorophenyl)methoxy]aniline | HCID 14182433 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 1-[4-(3-Chlorobenzyloxy)phenylamino] butane-2,3-diol | HCID 14182434 | 50.3% |
Reaction Steps
A solution containing 50 g (0.21 mol) of 4-(3'-chlorobenzyloxy) aniline and 21.6 g (0.24 mol) of the mixture obtained in Example 1 in 850 ml of isopropanol is refluxed for 6 hrs 30 mins. When the isopropanol has evaporated, the crude mixture is purified by flash silica chromatography (eluant: CH2Cl2 --CH3OH: 97-3). 34 g (yield: 49%) of white solid is recovered, corresponding to the product expected and having a melting point of from 95°-96° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04897409 |
| Source dataset | uspto-grants-1990_01 |
| ORD ID | ord-ac81e5ab09be41849730441ef2b47868 |
| Source note | uspto-grants-1990_01 |