反应详情

A solution containing 50 g (0.21 mol) of 4-(3'-chlorobenzyloxy) aniline and 21.6 g (0.24 mol) of the mixture obtained in Example 1 in 850 ml of isopropanol is refluxed for 6 hrs 30 mins. When the isopropanol has evaporated, the crude mixture is purified by flash silica chromatography (eluant: CH2Cl2 --CH3OH: 97-3). 34 g (yield: 49%) of white solid is recovered, corresponding to the product expected and having a melting point of from 95°-96° C.

1. temperatureis refluxed for 6 hrs 30 mins
2. customWhen the isopropanol has evaporated
3. customthe crude mixture is purified by flash silica chromatography (eluant: CH2Cl2 --CH3OH: 97-3)