HCID 13974075, compound → HCID 13974076, compound

HRID 330525Notes

Reaction equation

HRID 330525 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:9]=[C:10]1[N:14]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]([O:24][CH3:25])[CH:17]=2)[CH:13]([CH2:26][O:27]C2CCCCO2)[CH2:12][N:11]1[CH2:34][C:35]1[CH:40]=[CH:39][C:38]([O:41][CH3:42])=[C:37]([O:43][CH3:44])[CH:36]=1>Cl.CCO>[Cl:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[N:9]=[C:10]1[N:14]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]([O:24][CH3:25])[CH:17]=2)[CH:13]([CH2:26][OH:27])[CH2:12][N:11]1[CH2:34][C:35]1[CH:40]=[CH:39][C:38]([O:41][CH3:42])=[C:37]([O:43][CH3:44])[CH:36]=1

Participants

3

Reactant 1

HCID 13974075HCID 13974075, compound

Product 1

HCID 13974076HCID 13974076, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 21887872Ethanol hydrochlorideSolvent

Procedure

9.66 g (15 mmol) of (8) were treated for 6 hours with 30 ml of 2N HCl/EtOH solution (5:5). After extraction with EtOAc, 7.2 g of crude sample were obtained. After silica gel column separation, using EtOAc/Hexane (6:4) as solvent, 6.3 g of (9) (75% yield) were obtained.

Workup

  1. extractionAfter extraction with EtOAc, 7.2 g of crude sample
  2. customwere obtained
  3. customAfter silica gel column separation

Sources & evidence

ORD record
ord-2cadf2d5c4a2484fa8023b4a5bb5d5eb
Source dataset
uspto-grants-1990_01
Patent number
US04897412

Reaction notes

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