Hydrochloric Acid → HCID 57124953, compound

HRID 330533Notes

Reaction equation

HRID 330533 reaction equation
[O:1]=[C:2]1[C:6](=[C:7]([CH3:23])[CH:8]=[CH:9][C:10]2[CH:22]=[CH:21][C:13]([O:14][CH2:15][C:16]([O:18]CC)=[O:17])=[CH:12][CH:11]=2)[S:5][C:4](=[S:24])[NH:3]1.[OH-].[Na+].Cl>O>[O:1]=[C:2]1[C:6](=[C:7]([CH3:23])[CH:8]=[CH:9][C:10]2[CH:22]=[CH:21][C:13]([O:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:12][CH:11]=2)[S:5][C:4](=[S:24])[NH:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57311210HCID 57311210, compound

Product 1

HCID 57124953HCID 57124953, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 0.12 g of the isomer A of ethyl 4-[3-(4-oxo-2-thioxo-5-thiazolidinylidene)-1-buten-1-yl]phenoxyacetate prepared as described in Example 13, 5 ml of water and 1 ml of a 5% aqueous sodium hydroxide solution was stirred at room temperature for one hour. To the reaction mixture was added 10% hydrochloric acid to precipitate crystals. The crystals were recovered by filtration and washed with methanol to give 0.07 g of the isomer A of the desired 4-[3-(4-oxo-2-thioxo-5-thiazolidinylidene)-1-buten-1-yl]phenoxyacetic acid and also 0.07 g of the isomer B thereof.

Workup

  1. customprepared
  2. customto precipitate crystals
  3. filtrationThe crystals were recovered by filtration
  4. washwashed with methanol

Sources & evidence

ORD record
ord-555134af939049159294344b12fa3b6e
Source dataset
uspto-grants-1990_01
Patent number
US04897406

Reaction notes

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