Hydrochloric Acid → (Hexahydro-1H-pyrrolizin-7A-YL)methanamine

Temperature

20 °C

In 8.5 ml of acetic acid introduced therein hydrogen chloride gas (400 mg, 11.0 mmol), 7a-cyano-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine (300 mg, 2.20 mmol, obtained in Example 1) and platinum oxide (30 mg) were added to stir under hydrogen gas atmosphere for 24 hours at 20° C. After removal of insoluble matters from the reaction mixture, the filtrate was concentrated, 0.5N NaOH (10 ml) was added to the residue, which was extracted with chloroform, the extract was dried over anhydrous sodium sulfate, concentrated, and distilled in vacuo to afford 188 mg of the desired compound (Yield: 61%).

1. customAfter removal of insoluble matters from the reaction mixture
2. concentrationthe filtrate was concentrated
3. addition0.5N NaOH (10 ml) was added to the residue, which
4. extractionwas extracted with chloroform
5. dry with materialthe extract was dried over anhydrous sodium sulfate
6. concentrationconcentrated
7. distillationdistilled in vacuo

ORD record

ord-79c8bff648b14a5baa360b87af84f372

Source dataset

uspto-grants-1990_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04897495