Sodium Hydroxide → HCID 86743726, compound

HRID 330633Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:34]2[CH:39]=[CH:38][C:37]([F:40])=[CH:36][CH:35]=2)=[C:9]([C:28]2[N:32]([CH3:33])[N:31]=[N:30][N:29]=2)[CH:10]=[CH:11][C:12](=[O:27])[CH2:13][CH:14]([OH:26])[CH2:15][C:16]([O:18]CC2C=CC=CC=2)=[O:17])=[CH:4][CH:3]=1.[OH-].[Na+:42]>O1CCCC1.O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([C:34]2[CH:35]=[CH:36][C:37]([F:40])=[CH:38][CH:39]=2)=[C:9]([C:28]2[N:32]([CH3:33])[N:31]=[N:30][N:29]=2)[CH:10]=[CH:11][C:12](=[O:27])[CH2:13][CH:14]([OH:26])[CH2:15][C:16]([O-:18])=[O:17])=[CH:6][CH:7]=1.[Na+:42]

Participants

Conditions

Temperature: 24 °C

Procedure

Phenylmethyl 9,9-bis(4-fluorophenyl)-3-hydroxy-8-(1-methyl-1H-tetrazol-5-yl)-5-oxo-6,8-nonadienoate (0.34g, 0.62 mmole) was dissolved in tetrahydrofuran (4mL) and water (1mL). 1N Sodium hydroxide (0.62 mL, 0.62 mmole) was added, and the solution was stirred for 6 hours at 24° C. The mixture was diluted with water (10 mL) and washed with diethyl ether (3×50 mL). The aqueous portion was lyophilized to give 0.17 g (52%) of the title compound; m.p.=166°-180° C. (dec.).

Workup

washwashed with diethyl ether (3×50 mL)

Sources & evidence

ORD record: ord-04c9a4e1c92a496ea9fffd7ab1b71f66
Source dataset: uspto-grants-1990_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04897490

Reaction notes

Loading…