Ethyl 3,3-bis(4-fluorophenyl)-2-[2-(1-methylethyl) 2H-tetrazol-5-yl]-2-propenoate → 3,3-Bis(4-fluorophenyl)-2-[2-(1-methylethyl)-2H-tetrazol-5-yl]-2-propenal

HRID 330639Notes

Reaction equation

HRID 330639 reaction equation
FC1C=CC(C(C2C=CC(F)=CC=2)=C(C2N(C(C)C)N=NN=2)C(OCC)=O)=CC=1.[F:30][C:31]1[CH:36]=[CH:35][C:34]([C:37]([C:52]2[CH:57]=[CH:56][C:55]([F:58])=[CH:54][CH:53]=2)=[C:38]([C:44]2[N:45]=[N:46][N:47]([CH:49]([CH3:51])[CH3:50])[N:48]=2)[C:39](OCC)=[O:40])=[CH:33][CH:32]=1>>[F:30][C:31]1[CH:36]=[CH:35][C:34]([C:37]([C:52]2[CH:57]=[CH:56][C:55]([F:58])=[CH:54][CH:53]=2)=[C:38]([C:44]2[N:45]=[N:46][N:47]([CH:49]([CH3:51])[CH3:50])[N:48]=2)[CH:39]=[O:40])=[CH:33][CH:32]=1

Participants

3

Reactant 2

HCID 14723868Ethyl 3,3-bis(4-fluorophenyl)-2-[2-(1-methylethyl) 2H-tetrazol-5-yl]-2-propenoateHCID 14723869ethyl 3,3-bis(4-fluorophenyl)-2-[1-(1-methylethyl)-1H-tetrazol-5-yl]-2-propenoate

Product 1

HCID 147238743,3-Bis(4-fluorophenyl)-2-[2-(1-methylethyl)-2H-tetrazol-5-yl]-2-propenalYield 88%

Procedure

The general procedure of Example 21, Steps A, B, C, and D were repeated, except that the ethyl 3,3-bis(4-flurophenyl)-2-[1-(1-methylethyl)-1H-tetrazol-5-yl]-2-propenoate utilized therein was replaced by ethyl 3,3-bis(4-fluorophenyl)-2-[2-(1-methylethyl)-2H-tetrazol-5-yl]-2-propenoate and there was thereby produced in 88% yield the title compound.

Sources & evidence

ORD record
ord-c524880d3d194212948d1c2723140bcf
Source dataset
uspto-grants-1990_01
Patent number
US04897490

Reaction notes

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