Water → HCID 14096192, compound

HRID 330706Notes

Reaction equation

HRID 330706 reaction equation
[O:1]([CH2:8][C:9]([NH:11][C@H:12]1[CH2:16][O:15][N:14]([C:17]2([C:23]([O-:25])=[O:24])[CH2:21][CH2:20][C:19](=[O:22])[O:18]2)[C:13]1=[O:26])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Na+].[C:28]([O:34][CH2:35]Cl)(=[O:33])[C:29]([CH3:32])([CH3:31])[CH3:30].O>CN(C=O)C>[O:1]([CH2:8][C:9]([NH:11][C@H:12]1[CH2:16][O:15][N:14]([C:17]2([C:23]([O:25][CH2:35][O:34][C:28](=[O:33])[C:29]([CH3:32])([CH3:31])[CH3:30])=[O:24])[CH2:21][CH2:20][C:19](=[O:22])[O:18]2)[C:13]1=[O:26])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 87885Chloromethyl pivalateHCID 23696040HCID 23696040, compound

Product 1

HCID 14096192HCID 14096192, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Compound (28b) was dissolved in DMF, and chloromethyl pivalate was added to the solution, followed by stirring. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was concentrated, and hexane was added to the residue. The mixture was subjected to decantation twice and to further decantation (twice) with petroleum benzine. The residue was dried through a vacuum pump to give the subject Compound (28c).

Workup

  1. extractionthe mixture was extracted with ethyl acetate
  2. concentrationThe extract was concentrated
  3. additionhexane was added to the residue
  4. customThe residue was dried through a vacuum pump

Sources & evidence

ORD record
ord-4821edee12b04da29fc56b6ad772711f
Source dataset
uspto-grants-1990_01
Patent number
US04897489

Reaction notes

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