HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 86727989, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2,2-Difluoro-N-methylethan-1-amine--hydrogen chloride (1/1) | HCID 45792392 | — |
| Reactant | HCID 67998121 | HCID 67998121 | — |
| Product | HCID 86727989 | HCID 86727989 | — |
Reaction Steps
88.0 mg (0.50 mmol) 2-bromo-2-fluoropyridine, 78.9 mg (0.60 mmol) (2,2-difluoro-ethyl)-methyl-amine hydrochloride and 0.17 mL (1.00 mmol) DIPEA are stirred at 90° C. over night. The reaction is quenched by the addition of water and extracted with DCM. The combined org. layers are dried over MgSO4, filtered and the solvent is removend in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877741B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-fa724f70c7c0437fb9c2c24912c397c4 |
| Source note | uspto-grants-2014_11 |