Diisopropylethylamine → HCID 86727989, compound

HRID 330764Notes

Reaction equation

HRID 330764 reaction equation
[Br:1][C:2]1(F)[CH:7]=[CH:6][CH:5]=[CH:4][NH:3]1.Cl.[F:10][CH:11]([F:15])[CH2:12][NH:13][CH3:14].CCN(C(C)C)C(C)C>>[Br:1][C:2]1[N:3]=[C:4]([N:13]([CH2:12][CH:11]([F:15])[F:10])[CH3:14])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 457923922,2-Difluoro-N-methylethan-1-amine--hydrogen chloride (1/1)HCID 67998121HCID 67998121, compound

Product 1

HCID 86727989HCID 86727989, compound

Procedure

88.0 mg (0.50 mmol) 2-bromo-2-fluoropyridine, 78.9 mg (0.60 mmol) (2,2-difluoro-ethyl)-methyl-amine hydrochloride and 0.17 mL (1.00 mmol) DIPEA are stirred at 90° C. over night. The reaction is quenched by the addition of water and extracted with DCM. The combined org. layers are dried over MgSO4, filtered and the solvent is removend in vacuo.

Workup

  1. customThe reaction is quenched by the addition of water
  2. extractionextracted with DCM
  3. dry with materiallayers are dried over MgSO4
  4. filtrationfiltered

Sources & evidence

ORD record
ord-fa724f70c7c0437fb9c2c24912c397c4
Source dataset
uspto-grants-2014_11
Patent number
US08877741B2

Reaction notes

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