反应详情

10.0 g (57.5 mmol) 2-bromo-5-hydroxypyridine, 28.3 g (230 mmol) 1-bromopropane and 19.9 g (143.7 mmol) K2CO3 are added to 1 L ACN and stirred at reflux over night. Afterwards the reaction is quenched by the addition of water and extracted with TBME. The org. layers are combined, dried over MgSO4, filtered and the solvent is removed in vacuo. The crude product is purified by column chromatography (silica gel, PE/EtOAc).

1. temperatureat reflux over night
2. customAfterwards the reaction is quenched by the addition of water
3. extractionextracted with TBME
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. customthe solvent is removed in vacuo
7. customThe crude product is purified by column chromatography (silica gel, PE/EtOAc)